منابع مشابه
MicroRNA-200 Family Profile: A Promising Ancillary Tool for Accurate Cancer Diagnosis
Cancer is one of the most threatening diseases in the world and great interests have been paid to discover accurate and noninvasive methods for cancer diagnosis. The value of microRNA-200 (miRNA-200, miR-200) family has been revealed in many studies. However, the results from various studies were inconsistent, and thus a meta-analysis was designed and performed to assess the overall value of mi...
متن کاملThe MicroRNA-200 Family Is Upregulated in Endometrial Carcinoma
BACKGROUND MicroRNAs (miRNAs, miRs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. MicroRNAs are dysregulated in cancer and may play essential roles in tumorigenesis. Additionally, miRNAs have been shown to have prognostic and diagnostic value in certain types of cancer. The objective of this study was to identify dysregulated miRNAs in end...
متن کاملCirculating microRNA-200 Family as Diagnostic Marker in Hepatocellular Carcinoma
GOALS In this clinical study, we aimed to evaluate the role of circulating microRNA-200 family as a non-invasive tool to identify patients with cirrhosis-associated hepatocellular carcinoma (HCC). BACKGROUND Prognosis of HCC remains poor with increasing incidence worldwide, mainly related to liver cirrhosis. So far, no reliable molecular targets exist for early detection of HCC at surgically ...
متن کاملMicroRNA-200 Family Modulation in Distinct Breast Cancer Phenotypes
The epithelial to mesenchymal transition (EMT) contributes to tumor invasion and metastasis in a variety of cancer types. In human breast cancer, gene expression studies have determined that basal-B/claudin-low and metaplastic cancers exhibit EMT-related characteristics, but the molecular mechanisms underlying this observation are unknown. As the family of miR-200 microRNAs has been shown to re...
متن کاملTargeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells
Notch signalling is crucial for the correct development and growth of numerous organs and tissues, and when subverted it can cause cancer. Loss of miR-8/200 microRNAs (miRNAs) is commonly observed in advanced tumours and correlates with their invasion and acquisition of stem-like properties. Here, we show that this miRNA family controls Notch signalling activation in Drosophila and human cells....
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ژورنال
عنوان ژورنال: American Journal of Therapeutics
سال: 2016
ISSN: 1075-2765
DOI: 10.1097/mjt.0000000000000361